Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3

Antiviral activity of nucleoside analogues against norovirus.

BACKGROUND Norovirus (NoV) is the leading cause of epidemic gastroenteritis worldwide. The lack of a cell culture has significantly hampered the development of effective therapies against human NoV. Clinically approved nucleoside and non-nucleoside analogues have been used successfully against RNA viruses. METHODS In this study, we evaluated the efficacy of four nucleoside analogues (2'-C-MeC...

Antiviral Activity of 5-substituted Pyrimidine Nucleoside Analogues

From a large series of 5—substituted 1—(2—deoxy——D—ribofuranosyl)—ura— cil (dUrd) , 1—(2—deoxy——D—ribofuranosyl)—cytosine (dCyd) and 1—(—D—arabinofurano— syl)—uracil (araU) analogues that have been evaluated for their antiviral proper— ties, the (E)—5—(2—bromovinyl)derivatives emerged as the most potent and most selec— tive antiherpes agents. (E)—5—(2—Bromovinyl)—dUrd (BVDU) and its congeners, ...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Synthesis Optimization of Some Nucleoside Analogues Derivatives and Their Antiviral Activity

To prepare the target nucleosides, the branched chain sugars was converted to their active form (1-bromosugar derivatives). This conversion included the hydrolysis of bromination with hydrobromic acid (HBr) in glacial acetic acid, forming 1-bromo sugars (4,6-di-O-Acetyl-2,3-dideoxy-3,3-di-C-nitro methyl-Darabinohexopyranosyl bromide), which were subjected to condensation with theophylline mercu...

Novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations.

BACKGROUND Several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication of several herpes viruses. METHODS Established synthetic methods and antiviral and cytostatic activity assays were used for the evaluation of new 1,2,4-triazole and purine ac...